C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C12N 5/078 (2010.01) C12N 15/117 (2010.01) A61K 31/7125 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2386019
Methods and compositions are provided for extending the clinical utility of IFN-.alpha. in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-.alpha. treatment and reduce IFN-.alpha. treatment-related side effects. In addition, methods are provides for supporting the survival and for activating natural interferon producing cells (IPCs)in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
L'invention concerne des méthodes et des compositions permettant de prolonger l'utilité clinique d'IFN-.alpha. dans le traitement de plusieurs troubles viraux et proliférants. Parmi d'autres aspects, cette invention a trait à des méthodes qui permettent d'accroître l'efficacité du traitement IFN-.alpha. et de réduire les effets secondaires liés à ce traitement. En outre, ces méthodes servent à aider la survie et à activer les cellules (IPCs)in vitro productrices d'interférons naturels sans IL-3 exogène ou GM-CSF. Ladite invention repose sur la découverte, selon laquelle certains ISNA CpG et non CpG favorisent la survie et la stimulation d'IPC.
Bratzler Robert L.
Hartmann Gunther
Krieg Arthur
Coley Pharmaceutical Gmbh
Coley Pharmaceutical Group Inc.
Smart & Biggar
University Of Iowa Research Foundation
LandOfFree
Methods related to immunostimulatory nucleic acid-induced... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods related to immunostimulatory nucleic acid-induced..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods related to immunostimulatory nucleic acid-induced... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1367061