Methods, systems, and articles of manufacture for evaluating...

Details Methods, systems, and articles of manufacture for evaluating... Methods, systems, and articles of manufacture for evaluating...

G - Physics

06

F

G06F 19/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2416764

Methods, systems, and articles of manufacture consistent with the present invention are provided for making allele calls. In certain embodiments, allele calling is accomplished by providing a committee machine that receives calls from several allele calling algorithms. By receiving calls from multiple allele calling algorithms, the committee machine makes calls containing a high level of confidence over a variety of conditions. Certain embodiments provide methods employing at least two algorithms and at least two quality values for allele calling. Unique individual algorithms for allele calling are also provided.

L'invention concerne des procédés, systèmes et articles manufacturés destinés à réaliser des appels d'allèles. Dans certains modes de réalisation, l'appel d'allèles est effectué par une machine commune recevant des appels provenant d'une pluralité d'algorithmes d'appel d'allèles. Ladite machine commune effectue des appels présentant un degré de confiance élevé à différents niveaux. Dans d'autres modes de réalisation, les procédés selon l'invention consistent à employer au moins deux algorithmes et au moins deux valeurs de qualité pour l'appel d'allèle. L'invention concerne également des algorithmes individuels uniques destinés à l'appel d'allèle.

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