A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2592972
Embodiments of the invention disclosed herein relate to methods and compositions for bypassing the involvement of CD4+ cells when generating antibody and MHC class I-restricted immune responses, controlling the nature and magnitude of the response, and promoting effective immunologic intervention in viral pathogenesis. More specifically, embodiments relate to immunogenic compositions for vaccination particularly therapeutic vaccination, against HIV and other microbial pathogens that impact functioning of the immune system, their nature, and the order, timing, and route of administration by which they are effectively used.
Dans divers modes de réalisation, cette invention concerne des méthodes et des compositions qui empêchent l'implication de cellules CD4+ lors de la génération d'anticorps et de réponses immunitaires à des épitopes restreints du CMH de classe I, qui contrôlent la nature et l'ampleur de la réponse et qui favorisent une intervention immunologique efficace dans la pathogenèse virale. Plus précisément, l'invention concerne des compositions immunogènes pour la vaccination, en particulier la vaccination thérapeutique contre le VIH et autres agents pathogènes microbiens qui ont une incidence sur le fonctionnement du système immunitaire, leur nature, leur ordre, leur chronopharmacologie et la voie d'administration permettant de les utiliser efficacement.
Bot Adrian Ion
Diamond David C.
Mannkind Corporation
Perry + Currier
LandOfFree
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