Methods to diagnose and treat hiv-1 infection

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 39/00 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185129

The present invention provides a method for diagnosing HIV-1 infection in a subject by identifying the presence of anti-HIV-1 antibodies in the subject's serum that react with an autoantigen such as 70K. The invention also provides a method of stimulating an immune response against HIV-1 in a subject comprising immunizing the subject with an amino acid sequence of an autoantigen such as 70K that crossreacts with neutralizing epitopes present on HIV-1. The invention further provides a skin test that is useful for diagnosing a subject having an HIV-1 infection.

L'invention concerne un procédé de diagnostic d'infection à VIH-1 chez un sujet, consistant à identifier la présence d'anticorps anti-VIH-1 dans le sérum de ce dernier, lesquels réagissent avec un auto-antigen tel que 70k. L'invention concerne également un procédé de stimulation d'une réponse immune contre le VIH-1 chez un sujet consistant à immuniser ce dernier à l'aide d'une séquence d'acides aminés d'un auto-antigen tel que 70K, laquelle a une réaction croisée avec des épitopes neutralisants présent sur le VIH-1. En outre, l'invention présente un test cutané utile pour diagnostiquer une infection à VIH-1 chez un patient.

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