C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/0775 (2010.01) C12N 5/095 (2010.01) A61K 38/22 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2693144
The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.
L'invention concerne des compositions et des méthodes de diagnostic, de caractérisation et de traitement du cancer de l'ovaire. L'invention concerne en particulier des méthodes de traitement et/ou de prévention du cancer de l'ovaire chez une patiente, par l'administration d'une quantité efficace d'une substance anti-Müllérienne et/ou d'une quantité efficace d'un agent qui inhibe BCRP1. L'invention concerne également des méthodes permettant d'identifier et/ou d'enrichir des populations de cellules souches cancéreuses ovariennes et des populations de cellules souches somatiques ovariennes, en particulier d'enrichir des populations de cellules souches somatiques ovariennes coelomiques, de cellules souches somatiques ovariennes sous-coelomiques/stromales et de cellules souches somatiques ovariennes médullaires périphilaires. L'invention concerne encore des marqueurs de cellules souches somatiques ovariennes et des marqueurs de cellules souches cancéreuses ovariennes, ainsi que des méthodes d'identification d'agents inhibant de façon sélective la prolifération de cellules souches cancéreuses ovariennes par rapport à des cellules souches somatiques ovariennes.
Dombkowski David Michael
Donahoe Patricia K.
Maclaughlin David T.
Pieretti-Vanmarcke Rafael
Preffer Frederic
Gowling Lafleur Henderson Llp
The General Hospital Corporation
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