Methods to identify compounds that modulate neuronal activity

Details Methods to identify compounds that modulate neuronal activity Methods to identify compounds that modulate neuronal activity

G - Physics

01

N

G01N 33/68 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2385907

A specific amino acid sequence proximal to the carboxy terminus of P/Q type ion channels has been shown to mediate, through binding to the Homer protein, the expression of the gene encoding syntaxin-1A. This region of the P/Q type calcium ion channel provides peptides that can be used in screening assays for compounds that modulate the central nervous system.

On a démontré qu'une séquence d'acides aminés spécifique, située du côté proximal de la terminaison carboxy des canaux ioniques de type P/Q régule, en se liant avec la protéine Homer, l'expression du gène codant pour la syntaxine-1A. Cette région du canal ionique du calcium du type P/Q comprend des peptides qui peuvent être utilisés pour l'identification de composants modulateurs du système nerveux central.

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