Methods to identify evolutionarily significant changes in...

Details Methods to identify evolutionarily significant changes in... Methods to identify evolutionarily significant changes in...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/04 (2006.01) C40B 30/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2541189

Methods for identifying polynucleotide and polypeptide sequences which may be associated with commercially relevant or useful traits in prokaryotes are provided. The methods employ comparison of homologous genes from two closely related prokaryote species to identify evolutionarily significant changes. Sequences thus identified may be useful in developing therapeutics, diagnostics, or vaccines.

L'invention concerne des méthodes pour identifier des séquences polypeptidiques et polynucléotidique, pouvant être associées à des caractéristiques de procaryotes commercialement pertinentes ou utiles. Ces méthodes font appel à une comparaison de gènes homologues, à partir de deux espèces de procaryote étroitement liées, pour identifier des changements considérables d'évolution. Les séquences ainsi identifiées peuvent être utiles pour développer des thérapeutiques, des diagnostics ou des vaccins.

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