Methods to identify patients at risk of developing adverse...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2667812

The invention provides a method of screening patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is associated with an increased risk of treatment-emergent suicidal ideation, wherein the genotype is characterized by a polymorphism in a gene selected from the group consisting of glutamine receptor, ionotropic, kainate 2 (GRIK2); glutamate receptor ionotropic AMPA 3 (GRIA3); and combinations thereof.

La présente invention concerne une méthode de dépistage permettant d'identifier les patients qui sont davantage susceptibles de présenter un risque accru d'avoir des idées de suicide consécutives au traitement, laquelle méthode consiste : (a) à prélever un échantillon de matériel génétique sur les patients; et (b) à analyser l'échantillon pour détecter la présence, chez les patients, d'un génotype associé à un risque accru d'avoir des idées de suicide consécutives au traitement, lequel génotype se caractérise par un polymorphisme dans un gène sélectionné dans le groupe comprenant le gène GRIK2 (récepteur kaïnate 2 ionotrope au glutamate; le gène GRIA3 (récepteur AMPA 3 ionotrope au glutamate); et des combinaisons de ceux-ci.

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