Methods to identify polynucleotide and polypeptide sequences...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2318772

The present invention provides methods for identifying polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as disease (including susceptibility (human) or resistance (chimpanzee) to development of AIDS). The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.

La présente invention concerne des techniques d'identification de séquences de polynucléotides et de polypeptides chez l'homme et/ou chez les autres primates qui peuvent être associées à un état physiologique, tel que la maladie (y compris la vulnérabilité (humaine) ou la résistance (chimpanzé) au développement du SIDA). Les techniques consistent à comparer entre elles les séquences humaines et celles des autres primates, à l'aide de méthodes statistiques. On peut se servir des séquences identifiées comme cibles thérapeutiques hôtes et/ou dans les analyses de criblage.

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