Methods to maintain, improve and restore the cartilage...

Details Methods to maintain, improve and restore the cartilage... Methods to maintain, improve and restore the cartilage...

A - Human Necessities

61

L

A61L 27/38 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2646488

The present invention relates to regulatory cells, which are capable of restoring, maintaining or improving the stable cartilage phenotype of expanded and passaged chondrocytes. These regulatory cells are also capable of directing precursor and stem cells into the chondrogenic lineage. An enriched population of regulatory cells can be obtained by harvesting the non-adherent cells in the culture medium of a monolayer culture of PO chondrocytes.

L'invention concerne des cellules régulatrices aptes à restaurer, préserver ou améliorer le phénotype cartilagineux stable de chondrocytes en nombre accru ou cultivés par passages. Ces cellules régulatrices sont également aptes à diriger un précurseur et des cellules souches dans la lignée chondrogénique. Une population enrichie de cellules régulatrices peut être obtenue par récolte des cellules non adhérentes dans le milieu de culture d'une culture monocouche de chondrocytes PO.

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