Methods to mediate polyketide synthase module effectiveness

Details Methods to mediate polyketide synthase module effectiveness Methods to mediate polyketide synthase module effectiveness

C - Chemistry, Metallurgy

12

P

C12P 19/62 (2006.01) C12N 9/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2359801

The linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides. The modules are provided suitable linkers so that the polyketide chain is passed from one module to the other in the correct sequence.

Les séquences de liaison qui modulent les perturbations entre des modules de polykétide-synthases de type I ont été identifiées. Ainsi, il est possible de mélanger et d'apparier des modules choisis arbitrairement en utilisant les séquences de liaison appropriées qui permettent d'obtenir des polykétide-synthases souhaitées et de nouveaux polykétides. On associe aux modules des séquences de liaison adaptées de sorte que la chaîne polykétidique passe d'un module à l'autre selon un séquencement correct.

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