Methods to predict and prevent resistance to taxoid compounds

Details Methods to predict and prevent resistance to taxoid compounds Methods to predict and prevent resistance to taxoid compounds

A - Human Necessities

61

K

A61K 38/08 (2006.01)

Patent

CA 2630214

Embodiments of the invention are directed to methods for predicting the resistance of cancer to members of the taxoid family by measuring the levels of prohibitin. Methods for treating cancer and taxoid family member resistant cancers using inhibitors of prohibitin, as well as therapeutic complexes that target prohibitin are also provided.

L'invention porte dans ses variantes: sur des méthodes de prédiction de la résistance de cancers à des éléments de la famille des taxoïdes par mesure des niveaux de prohibitine; sur des méthodes de traitement de cancers et de cancers résistant à des éléments de la famille des taxoïdes par utilisation d'inhibiteurs de la prohibitine; et sur des complexes thérapeutiques ciblant la prohibitine.

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