Methods to predict edema as a side effect of drug treatment

Details Methods to predict edema as a side effect of drug treatment Methods to predict edema as a side effect of drug treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2501095

This invention provides methods to predict the likelihood of occurrence of the side effect of edema in patients treated with a drug including, but not limited to, a TKI, such as Imatinib or GLEEVEC.TM./GLIVEC®. The methods employed use gene expression profile comparisons and the determination of specific SNPs and in the IL-1.beta. gene. Methods of treatment of edema and kits for the performance of the above assays are also provided.

L'invention concerne des méthodes permettant de prévoir la probabilité d'apparition d'effets secondaires oedémateux chez des patients traités par médicaments comprenant, sans aspect limitatif, un inhibiteur de tyrosine kinase (TKI), comme Imatinib ou GLEEVEC<SP>TM</SP>/GLIVEC ®. Les méthodes utilisées font appel à des comparaisons de profils d'expression génique et à la détermination de SNP spécifiques et dans le gène IL-1.beta.. L'invention concerne également des méthodes de traitement de l'oedème et des trousses appropriées pour effectuer les dosages biologiques mentionnés précédemment.

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