Methods to reduce oxalate concentration by administration of...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/02 (2006.01) A61K 38/44 (2006.01) A61K 47/48 (2006.01) A61P 1/18 (2006.01) A61P 13/04 (2006.01) A61P 13/12 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2610159

The invention relates to methods to prevent, treat, or slow the progression of a disorder associated with elevated oxalate concentration, the method comprising administering oxalate oxidase crystals, cross-linked crystals, or compositions containing those crystals to an individual. Oxalate oxidase crystals and compositions for administration to an individual are also provided, including stabilized crystals, such as cross-linked crystals of oxalate oxidase.

L'invention concerne des procédés permettant de prévenir, de traiter ou de ralentir la progression d'un trouble associé à une teneur élevée d'oxalate. Le procédé consiste à administrer au patient des cristaux d'oxalate oxydase, des cristaux réticulés, ou des compositions contenant ces cristaux. L'invention concerne également des cristaux et compositions d'oxalate oxydase à administrer au patient, y compris des cristaux stabilisés, tels que les cristaux réticulés d'oxalate oxydase.

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