C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C12N 7/06 (2006.01)
Patent
CA 2345230
The invention features a method for inactivating animal viruses in a preparation of purified mammalian cells which, when mature, lack a nucleus (e.g., red blood cells or platelets), that includes contacting the preparation with a selective ethyleneimine oligomer inactivating agent under viral inactivating conditions for a period of time sufficient to inactivate at least some of the animal viruses in the preparation. Also disclosed is a method for removing the ethyleneimine oligomer inactivating agent from a treated biological composition, following viral inactivation without the addition of any quenching agent.
L'invention porte sur un procédé d'inactivation de virus d'animaux dans une préparation de cellules purifiées de mammifères qui arrivées à maturité n'ont pas de noyau (par exemple des globules rouges ou des plaquettes), consistant à mettre en contact la préparation avec un agent inactivateur sélectif, oligomère d'éthylèneimine, dans des conditions d'inactivation pendant un temps suffisant pour inactiver au moins certains virus de la préparation. L'invention porte également sur un procédé d'extraction, après le processus d'inactivation, des virus dudit agent inactivateur de la composition biologique traitée, sans adjonction d'un agent d'extinction.
Ackerman Samuel K.
Edson Clark Mcwhorter
Purmal Andrei A.
Mbm Intellectual Property Law Llp
V.i. Technologies Inc.
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