Methods using 1, 2-dithiol-3-thiones and their derivatives...

Details Methods using 1, 2-dithiol-3-thiones and their derivatives... Methods using 1, 2-dithiol-3-thiones and their derivatives...

A - Human Necessities

61

K

A61K 31/4985 (2006.01) A61K 31/497 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2461916

Novel methods for, inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative 'Or metabolite thereof. Preferred compounds for use in the methods include 5-(2- pyrazinyl)-4methyl-1, 2-dithiol-3-thione (Oltipraz) and its metabolites.

L'invention porte sur de nouvelles méthodes d'inhibition de l'angiogenèse, et de traitement de maladies associées à l'angiogenèse, consistant à administrer à un patient une quantité efficace d'un dérivé de la 1,2-dithiol-3-thione ou l'un de ses métabolites. Les composés préférés utilisés comprennent la 5-(2-pyrazinyl)-4méthyl-1,2-dithiol-3-thione (Oltipraz) et ses métabolites.

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