Methods using phage display for selecting internalizing...

Details Methods using phage display for selecting internalizing... Methods using phage display for selecting internalizing...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2302292

A bacteriophage system is presented for selecting internalizing ligands for gene delivery. The bacteriophage carries a reporter or selectable marker and presents a ligand on its surface. More specifically, a library of potential ligands may be screened for the ability to successfully transduce target cells.

L'invention concerne un système de bactériophage présenté pour sélectionner des ligands internalisants en vue d'une administration de gène. Le bactériophage porte un rapporteur ou un marqueur pouvant être sélectionné, et présente un ligand sur sa surface. De manière plus spécifique, une banque de ligands potentiels peut être criblée pour rechercher les ligands présentant une capacité de transduire avec succès des cellules cibles.

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