A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2523600
An association is disclosed between the elevated levels of the G-protein coupled receptor 54 (GPR54) and certain cell proliferative diseases, such as kidney cancer. The invention further relates to screening methods to identify compounds that interact with the G-protein coupled receptor to identify agonists and antagonists for diagnosis and treatment. The invention also relates to directed targeting using agents that interact with GPR54, (e.g., anti-GPR54 antibodies or peptide agonists) which are coupled to a toxin.
L'invention concerne l'association entre un niveau élevé du récepteur 54 couplé à une protéine G (GPR54) et certaines maladies cellulaires prolifératives, telles que le cancer du rein. L'invention concerne également des procédés de criblage permettant d'identifier des composés qui interagissent avec ledit récepteur couplé à une protéine G pour identifier des agonistes et des antagonistes utiles dans le diagnostic et dans le traitement de la maladie. L'invention concerne encore un ciblage dirigé utilisant des agents qui interagissent avec le GPR54 (des anticorps anti-GPR54 ou des agonistes de peptides, par exemple) et qui sont couplés à une toxine.
Torys Llp
Wyeth
LandOfFree
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