C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/525 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2270176
The present invention relates to a method of producing certain peptides containing methylated arginines that are followed by a glycine residue and that constitute immunogenic determinants of antibodies present in sera from patients with systemic lupus erythematosus, or Epstein-Barr virus and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptides for diagnosis and treatment of systemic lupus erythematosus and related diseases, and diseases in which Epstein-Barr virus has been implicated.
Cette invention a trait à une technique de production de certains peptides, contenant des arginines méthylées suivies d'un reste de glycine, lesquels peptides constituent des déterminants immunogènes d'anticorps présents dans des sérums de patients atteints du lupus érythémateux disséminé ou infectés par le virus Epstein-Barr, la méthylation étant une condition préalable au déclenchement d'une réaction avec lesdits anticorps. Cette invention concerne également l'utilisation de ces peptides aux fins du diagnostic et du traitement du lupus érythémateux disséminé et à ceux d'autres maladies connexes ainsi que de maladies liées au virus Epstein-Barr.
Luhrmann Reinhard Georg
Meheus Lydie
Raymackers Joseph
Union Ann
Innogenetics N.v.
Smart & Biggar
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