Methylation of estrogen receptor alpha and uses thereof

Details Methylation of estrogen receptor alpha and uses thereof Methylation of estrogen receptor alpha and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/12 (2006.01) A61K 38/15 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2648160

Methods for diagnosis, prognosis, and treatment of cancer based on the methylation status of the ER-.alpha. gene promoter are disclosed. Methylation of the ER-.alpha. gene promoter is indicative of cancer and unfavorable prognosis. The cancer can be treated with a demethylation agent.

L'invention concerne des procédés de diagnostic, de pronostic, et de traitement du cancer basés sur l'état de méthylation du promoteur du gène ER-.alpha.. La méthylation du promoteur du gène ER-.alpha. indique le cancer ou un pronostic défavorable. Le cancer peut être traité avec un agent de déméthylation.

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