Methylation of genes as a predictor of polyp formation and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2645015

The present invention provides methods for identifying or assessing probabilities for developing an abnormal condition in subject and for the recurrence of the abnormal condition in the subject after receiving treatment. The method comprises determining the methylation status of at least one gene in the subject and comparing this methylation status to normal methylation status. Differences between the methylation status of the one or more genes is indicative of the subject developing an abnormal condition or for the recurrence of the abnormal conditions after receiving treatment.

La présente invention concerne des procédés d'identification ou d'évaluation des probabilités de développement d'une pathologie chez un sujet et de la réapparition de cette pathologie chez le sujet après qu'il ait reçu un traitement. Le procédé consiste à déterminer l'état de méthylation d'au moins un gène du sujet et à comparer cet état de méthylation à un état de méthylation normal. Les différences entre l'état de méthylation d'un ou de plusieurs gènes est une indication du développement d'une pathologie chez le sujet ou de la réapparition de la pathologie après un traitement.

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