A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2452628
The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and H2A peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-translational modifications of a histone modification cassette SGRGK (SEQ ID NO: 1), wherein the modifications are selected from the group consisting of a phosphorylated serine, methylated arginine and acetylated lysine. Compositions comprising these antibodies are used as diagnostic and screening tools.
L'invention concerne la génération d'anticorps qui se lient à des modifications spécifiques de la terminaison amino des peptides d'histone H3 et H2A. L'invention porte notamment sur la génération d'un ensemble d'anticorps qui reconnaissent diverses modifications post-traductionnelles d'une cassette de modification d'histone SGRGK (SEQ ID NO: 1), les modifications étant sélectionnées dans le groupe constitué d'une sérine phosphorylée, d'arginine méthylée et de lysine acétylée. Des préparations comprenant les anticorps de l'invention sont utilisées dans des outils diagnostiques et de criblage.
Allis C. David
Briggs Scott D.
Strahl Brian D.
Sim & Mcburney
University Of Virginia Patent Foundation
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