Methylen-oxindole derivatives and process for their preparation

Details Methylen-oxindole derivatives and process for their preparation Methylen-oxindole derivatives and process for their preparation

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/40 (2006.01) C07D 209/34 (2006.01)

Patent

CA 2091058

The invention provides new methylen-indole derivatives of formula (I), wherein R is a group (a) in which R4 is hydrogen, hydroxy, C1-C6 alkoxy, C2-C6 alkanoyloxy, carboxy, nitro or NHR7, wherein R7 is hydrogen or C1-C6 alkyl; R5 is hydrogen, C1-C6 alkyl or halogen; and R6 is hydrogen or C1-C6 alkyl; n is zero, 1 or 2; R1 is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; R2 is hydrogen, C1-C6 alkyl, halogen, cyano, carboxyl, nitro or -NHR7 in which R7 is as defined above; R3 is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; and the pharmaceutically acceptable salts thereof; and wherein, when, at the same time, R2 is hydrogen, C1-C6 alkyl, halogen or cyano and R3 is hydrogen, R1 and n being as defined above, then at least one of R4, R5 and R6 is other than hydrogen, which are useful as tyrosine kinase inhibitors.

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