Methylenetetrahydrofolate reductase inhibitors and use thereof

Details Methylenetetrahydrofolate reductase inhibitors and use thereof Methylenetetrahydrofolate reductase inhibitors and use thereof

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 9/06 (2006.01) C12N 15/11 (2006.01) C12N 15/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2429583

The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an antisense oligonucleotide, a ribozyme, a triple helix forming oligonucleotide, an anti-MTHFR antibody or fragment thereof, an MTHFR mutant or a fragment of MTHFR. The present invention further provides nucleic acids encoding an inhibitor of MTHFR, and vectors comprising these nucleic acids. Also encompassed by the present invention are methods of using the MTHFR inhibitors for selective inhibition of cancer cell growth, and pharmaceutical compositions comprising the MTHFR inhibitors.

L'invention concerne des inhibiteurs de la méthylènetétrahydrofolate réductase (MTHFR), utiles dans l'inhibition sélective de la croissance cellulaire cancéreuse, chez un mammifère. Ces inhibiteurs peuvent être une petite molécule, un oligonucléotide antisens, un ribozyme, un oligonucléotide formant une hélice triple, un anticorps dirigé contre la MTHF réductase, ou un fragment de cet anticorps, un mutant ou un fragment de la MTHF réductase. L'invention concerne en outre des acides nucléiques codant pour un inhibiteur de la MTHF réductase, ainsi que des vecteurs comprenant ces acides nucléiques. L'invention porte également sur des procédés d'utilisation des inhibiteurs de la MTHF réductase, aux fins d'inhibition sélective de la croissance cellulaire cancéreuse, de même que sur des compositions pharmaceutiques comprenant ces inhibiteurs.

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