Methylphenidate analogs and methods of use thereof

Details Methylphenidate analogs and methods of use thereof Methylphenidate analogs and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 211/12 (2006.01) A61K 31/4458 (2006.01) A61P 25/28 (2006.01) C07D 211/14 (2006.01)

Patent

CA 2585014

Provided are analogs of methylphenidate (~MPH~) that are useful for the treatment of drug addiction, attention deficit disorder, attention deficit hyperactivity disorder, and depression. The MPH analogs are extend duration compounds that bind to the dopamine transporter and the reuptake of dopamine in the afflicted individual~s brain. Becauses of the extend duration of the MPH analogs, administration of the compounds is only required on a once or twice daily schedule.

L'invention concerne des analogues de méthylphénidate ( MPH ) utilisés dans le traitement de la toxicomanie, des troubles du déficit d'attention, de l'hyperactivité avec déficit d'attention et de la dépression. Lesdits analogues de MPH sont des composés à durée d'action prolongée qui se lient aux transporteurs de la dopamine et qui inhibent la réabsorption de la dopamine dans le cerveau des individus atteints. La durée d'action prolongée desdits analogues de MPH permet de n'administrer lesdits composés qu'une ou deux fois par jour.

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