Methylthioribose analogs, their preparation and use as...

Details Methylthioribose analogs, their preparation and use as... Methylthioribose analogs, their preparation and use as...

C - Chemistry, Metallurgy

07

H

167/185, 260/233

C07H 5/02 (2006.01) A61K 31/70 (2006.01) C07H 15/14 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1284498

"METHYLTHIORIBOSE ANALOGS, THEIR PREPARATION AND USE AS MEDICINAL AGENTS AND BIOCIDES" ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image wherein R is H, Cl, F, Br, I or R1S-, in which R1 is C1- C10 linear or branched chain alkyl or halogenated linear or branched chain alkyl, and wherein R2, R3 and R4 are the same or different and each is H- or -OH, with the proviso that at least one of R2, R3 and R4 is hydroxy and the further proviso that when R2, R3 and R4 are all OH, R1 is halogenated linear or branched chain alkyl, are useful in inhibiting the growth of MTR kinase-dependent microorganisms and parasitic protozoans. The compounds wherein R is R1S are novel, except those excluded by the above provisions.

527749

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