Mevinic acid derivatives

Details Mevinic acid derivatives Mevinic acid derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/357

C07C 235/26 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 235/06 (2006.01) C07C 235/08 (2006.01) C07C 235/16 (2006.01) C07D 295/185 (2006.01) C07D 309/30 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2016674

HX22 Abstract MEVINIC ACID DERIVATIVES Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula I Image wherein: R1, R2 and R3 are independently selected from: (1) alkyl, (2) substituted alkyl in which one or more substituents are selected from (a) halogen, (b) hydroxyl, (c) alkoxy, (d) alkoxycarbonyl, (e) acyloxy, (f) cycloalkyl, (g) phenyl, (h) substituted phenyl in which one or more substituents are X or Y, (i) alkyl-S(O)n, (j) cycloalkyl-S(O)n, HX22 (k) phenyl-S(O)n, (1) substituted phenyl-S(O)n in which one or more substituents are X or Y, and (m) oxo, (3) alkoxy, (4) alkenyl, (5) cycloalkyl, (6) substituted cycloalkyl in which one or more substitutents are selected from (a) alkyl, (b) substituted alkyl in which one or more substituents are selected from (i) halogen, (ii) hydroxy, (iii) alkoxy, (iv) alkoxycarbonyl (v) acyloxy (vi) phenyl (vii) substituted phenyl in which one or more substituents are X and Y, (viii) alkyl-S(O)n, (ix) cycloalkyl-S(O)n, (x) phenyl-S(O)n, (xi) substituted phenyl-S(O)n in which one or more substituents are X and Y, and (xii) oxo, (c) alkyl-S(O)n, (d) cycloalkyl-S(O)n, HX22 (e) phenyl-S(O)n, (f) substituted phenyl-S(O)n in which one or more substituents are X or Y, (g) halogen, (h) hydroxy, (i) alkoxy, (j) alkoxycarbonyl, (k) acyloxy, (l) phenyl, and (m) substituted phenyl in which one or more substituents are X and Y, (7) phenyl, (8) substituted phenyl in which one or more substituents are X or Y, (9) amino, (10) alkylamino, (11) dialkylamino, (12) phenylamino, (13) substituted phenylamino in which one or more substituents are X or Y, (14) alkyl(substituted phenyl)amino in which one or more substituents are X and Y, (15) phenylalkylamino, (16) di(phenylalkyl)amino, (17) substituted phenylalkylamino in which one or more substituents are X or Y, (18) a member selected from (a) piperidinyl, (b) pyrrolidinyl, (c) piperazinyl, (d) morpholinyl, HX22 (e) thiomorpholino, (f) histaminyl, (g) 3-aminomethyl pyridinyl, and (19) hydroxy substituted alkylamino; X and Y are independently hydrogen, halogen, trifluoromethyl, alkyl, nitro, alkoxy, or cyano; n is 0, 1, or 2; Image or Image ; and M+ is hydrogen, ammonium, or an alkali metal.

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