Mhc binding peptide oligomers and methods of use

Details Mhc binding peptide oligomers and methods of use Mhc binding peptide oligomers and methods of use

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) C12N 9/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262001

Disclosed are oligomers comprising at least two MHC binding peptides joined by a flexible molecular linker. The MHC binding peptides can be MHC class I binding peptides or MHC class II binding peptides. Also disclosed is an oriented cloning method for producing such oligomers. The disclosed oligomers can be used, for example, in connection with methods for specifically activating or inhibiting the activation of CD4+ or CD8+ T cells. Such methods provide therapeutic approaches for the treatment of tumors, autoimmune disorders, allograft rejection and allergic reactions.

On décrit des oligomères comprenant au moins deux peptides de fixation du complexe majeur d'histocompatibilité (CMH), joints par une séquence de liaison moléculaire souple. Ces peptides de fixation du CMH peuvent être des peptides de la classe I ou de la classe II. On décrit également un procédé de clonage orienté, destiné à produire de tels oligomères. On peut utiliser les oligomères décrits, par exemple, en rapport avec des procédés destinés à activer ou inhiber de manière spécifique l'activation de lymphocytes T CD4?+¿ ou CD8?+¿. De tels procédés constituent des approches thérapeutiques au traitement de tumeurs, de désordres auto-immuns, de rejet de greffe allogénique et de réactions allergiques.

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