C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2476165
There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No.2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No.3; (iii) the minimal epitope from the amino acid sequence shown as SEQ ID No.4. (iv) the minimal epitope from the amino acid sequence shown as SEQ ID No. 5. (v) the minimal epitope from the amino acid sequence shown as SEQ ID No.6. (vi) the minimal epitope from the amino acid sequence shown as SEQ ID No.7. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.
La présente invention concerne un épitope peptidique de classe I MHC de l'antigène 5T4 et plus particulièrement un épitope peptidique de 5T4 qui comprend une des séquences suivantes: (i) la séquence d'acides aminés SEQ ID No.2; (ii) l'épitope minimal provenant de la séquence d'acides aminés SEQ ID No.3; (iii) l'épitope minimal provenant de la séquence d'acides aminés SEQ ID No.4. (iv) l'épitope minimal provenant de la séquence d'acides aminés SEQ ID No. 5. (v) l'épitope minimal provenant de la séquence d'acides aminés SEQ ID No.6. (vi) l'épitope minimal provenant de la séquence d'acides aminés SEQ ID No.7. Cette invention concerne également un vaccin comprenant un tel peptide (ou un précurseur de ce peptide) et l'utilisation de ce dernier pour traiter et/ou prévenir une maladie, notamment une maladie cancéreuse.
Carroll Miles
Kingsman Susan
Redchenko Irina
Idm S.a.
Oxford Biomedica Uk Limited
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