C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 35/14 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C07K 17/00 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2254975
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
La présente invention concerne des matrices synthétiques de présentation d'antigènes, leurs procédés de fabrication et leurs procédés d'utilisation. L'une de ces matrices est constituée de cellules qui ont été transfectées dans le but de produire des molécules de présentation d'antigènes du CMH et une ou plusieurs molécules accessoires. Ces matrices sont utilisées pour activer des lymphocytes T à CD4<+> naïfs ainsi que pour transformer l'état d'activation permanente en une population différenciée préférée de cellules Th1 ou Th2.
Jackson Michael R.
Karlsson Lars
Peterson Per A.
Webb Susan R.
Winqvist Ola
Fetherstonhaugh & Co.
The Scripps Research Institute
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