Mhc class ii haplotype specific immunodominancy of peptides...

G - Physics – 01 – N

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G01N 33/68 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2489907

The present invention relates immunodominant peptides derived from human respiratory syncytial virus (H-RSV) that may be used in ex vivo diagnosis of immune responses to H-RSV. The immunodominant peptides are derived from the H- RSV Fusion (F) and Attachment (G) proteins and are capable of inducing an antigen specific CD4+ T cell response ex vivo in a MHC class 11 haplotype restricted manner. The immunodominant H-RSV-derived peptides may further be used in methods for vaccination against H-RSV, preferably in a MHC class 11 haplotype specific manner.

L'invention concerne des peptides immunodominants dérivés du virus respiratoire syncytial humain (H-RSV) qui peuvent être utilisés dans le diagnostic ex vivo des réponses immunitaires à H-RSV. Ces peptides immunodominants sont dérivés des protéines de fusion (F) et de fixation (G) de H-RSV et sont capables d'induire une réponse lymphocytaire T spécifique des antigènes CD4?+¿ ex vivo de manière restreinte à l'haplotype du CMH classe II. Les peptides immunodominants dérivés du H-RSV peuvent également être utilisés dans des méthodes de vaccination contre le H-RSV, de préférence de manière spécifique de l'haplotype du CMH classe II.

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