Mhc complexes and uses thereof

Details Mhc complexes and uses thereof Mhc complexes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) A61P 37/00 (2006.01) C07K 14/74 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2244755

The present invention relates to novel complexes of major histocompatibility complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

Nouveaux complexes de molécules de complexe majeur d'histocompatibilité (CMH) et leurs utilisations. Selon l'un de ces aspects, l'invention porte sur des complexes majeurs d'histocompatibilité (CMH) chargés comprenant au moins une molécule CMH présentant une rainure de liaison peptidique, et un peptide donneur à liaison non covalente avec la protéine CMH. Selon un autre aspect, l'invention se caractérise par des complexes de fusion peptidique de classe II de CMH à chaîne unique dotés d'un peptide donneur lié de manière covalente à la rainure de liaison peptidique du complexe. Les complexes CMH de cette invention se révèlent utiles pour toute une série d'application, notamment: 1) les dépistages in vitro d'identification et d'isolement de peptides modulant l'activité de lymphocytes T choisis, y compris des peptides qui sont des antagonistes et des agonistes partiaux du récepteur des lymphocytes T, et 2) des méthodes de neutralisation ou d'induction d'une réponse immune chez un mammifère.

Affiliated with

Also associated with

Rating

Mhc complexes and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mhc complexes and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mhc complexes and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1765811