Mhc-mediated toxic conjugates useful in ameliorating...

Details Mhc-mediated toxic conjugates useful in ameliorating... Mhc-mediated toxic conjugates useful in ameliorating...

C - Chemistry, Metallurgy

07

K

167/129, 530/15.

C07K 14/74 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 51/12 (2006.01) C07K 14/78 (2006.01)

Patent

CA 1340327

The invention is directed to methods and material useful in treating autoimmune diseases. The therapeutic agents are of the formula X1MHC2peptide or MHC2peptide1X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen; 1 represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and 2 represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.

603841

Affiliated with

Also associated with

Rating

Mhc-mediated toxic conjugates useful in ameliorating... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mhc-mediated toxic conjugates useful in ameliorating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mhc-mediated toxic conjugates useful in ameliorating... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1320870