C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/15.
C07K 14/74 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 51/12 (2006.01) C07K 14/78 (2006.01)
Patent
CA 1340327
The invention is directed to methods and material useful in treating autoimmune diseases. The therapeutic agents are of the formula X1MHC2peptide or MHC2peptide1X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen; 1 represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and 2 represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.
603841
Clark Brian R.
Lerch L. Bernard
Sharma Somesh D.
Anergen Inc.
Battison Williams Dupuis
Biospan Corporation
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