C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2131433
Abstract MICE DEFICIENT IN NEUROTROPHIN RECEPTORS The present invention provides mice and mouse cell lines having a homozygous or heterozygous deficiency in a gene encoding a neurotrophin receptor. In a preferred embodiment of this invention, mice and cell lines carry a trkB locus specifically targeted within its tyrosine protein kinase sequences. Mice homozygous for this mutation express gp95trkB receptor of unknown function but not the high affinity functional gp145trkB tyrosine protein kinase receptors. This mutation results in multiple CNS and PNS neuronal deficiencies and in a postembryonic lethal phenotype. Such genetically modified mice are useful in model systems for studying human diseases involving neuronal degeneration and neuronal cell loss, as well as in screening for genes, proteins, or other compounds that may prevent or impede neuronal cell death or stimulate neuronal regeneration.
Barbacid Mariano
Joyner Alexandra
Klein Rudiger
Barbacid Mariano
Joyner Alexandra
Klein Rudiger
Osler Hoskin & Harcourt Llp
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