Micelle composition of polymer and passenger drug

Details Micelle composition of polymer and passenger drug Micelle composition of polymer and passenger drug

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 9/107 (2006.01) A61K 31/337 (2006.01) A61K 31/436 (2006.01) A61K 47/22 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2603987

Hydrophobic drags become more practical for treatments by being encapsulated in micelle compositions for increasing solubility. Micelle compositions may include an excipient tocopherol and/or prodrug formulations of the drug. Micelles extend the time period the drag remains in the micelles to improve drag circulation time and thereby drag delivery. Hydrophobic drags for micelle encapsulation may include rapamycin, geldanamycin, and paclitaxel.

L'encapsulation de médicaments hydrophobes dans des compositions micellaires, qui augmentent leur solubilité, les rend plus faciles à utiliser dans le cadre de traitements. Les compositions micellaires selon l'invention peuvent contenir un excipient de tocophérol et/ou des formules de promédicaments du médicament. Les micelles allongent la période pendant laquelle le médicament reste dans les micelles, afin d'améliorer la durée de circulation du médicament et ainsi la distribution de ce dernier. Parmi les médicaments hydrophobes destinés à une encapsulation micellaire, l'on compte la rapamycine, la geldanamycine et le paclitaxel. L'administration desdites compositions micellaires rend inutile l'utilisation de Cremophor EL ou de Polysorbate 80, ce qui permet d'éviter les graves effets secondaires associés auxdits produits, qui accompagnaient jusqu'à maintenant l'administration de tels médicaments.

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