Michael systems as transglutaminase inhibitors

Details Michael systems as transglutaminase inhibitors Michael systems as transglutaminase inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) C07K 1/02 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2662876

The invention relates to peptide derivatives and peptidomimetic agents as transglutaminase inhibitors. The invention also relates to methods for the production of said compounds, to pharmaceutical compositions containing the same, and to uses of the transglutaminase inhibitors, especially for treating coeliac disease and other transglutaminase-dependent diseases.

L'invention concerne des dérivés peptidiques et des analogues de peptides utilisés comme inhibiteurs de la transglutaminase, leur procédé de production, les compositions pharmaceutiques contenant ces composés et l'utilisation des inhibiteurs de la transglutaminase notamment pour le traitement de l'intolérance au gluten et autres maladies liées à la transglutaminase.

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