A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2694928
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR- 208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
L'invention concerne l'identification de deux microARN, miR-499 et miR-208b, qui répriment les gènes de protéines contractiles des muscles squelettiques rapides. L'expression de miR-499 et/ou de miR-208b peut servir à réprimer les gènes de fibres rapides et à activer les gènes de fibres lentes dans le traitement de troubles musculosquelettiques. Selon l'invention, l'inhibition de miR-499 et/ou de miR-208b permet de traiter une hypertrophie cardiaque, un infarctus du myocarde, et/ou une insuffisance cardiaque. L'invention concerne également des compositions pharmaceutiques comprenant des antagonistes et des agonistes de la fonction miR-499 et miR-208b.
Olson Eric
Rooij Eva Van
Board Of Regents The University Of Texas System
Deeth Williams Wall Llp
LandOfFree
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