Microarray fabrication techniques and apparatus

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01) B01L 3/00 (2006.01) B01L 3/02 (2006.01) G01N 21/25 (2006.01) G01N 21/64 (2006.01) B81B 1/00 (2006.01) G01N 35/10 (2006.01)

Patent

CA 2400789

Disclosed is a microarray printing system (100) and methods of printing probe microarrays (1101). The system has a print head (101, 200, 805, 1003, 1700, 1800, 1900) formed of one or more bundles (201-221, 604) of individual capillaries, (102, 301, 402a, 402b, 502a, 502b, 603a, 603b, 802) such as light- guiding capillaries. The bundles may especially be random bundles of capillaries that provide a large number of probes (807, 1006a, 1006b, 1206) on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.

L'invention concerne un système d'impression (100) de jeux ordonnés de microéchantillons et des procédés d'impression de jeux ordonnés de microéchantillons (1101) pourvus de sondes. Le système comporte une tête d'impression (101, 200, 805, 1003, 1700, 1800, 1900) formée d'un ou de plusieurs faisceaux (201-221, 604) de capillaires (102, 301, 402a, 402b, 502a, 502b, 603a, 603b, 802) individuels, tels que des capillaires de guidage de lumière. Les faisceaux peuvent être notamment des faisceaux de capillaires aléatoires qui produisent un grand nombre de sondes (807, 1006a, 1006b, 1206) à la surface d'un substrat. L'invention concerne aussi des procédés permettant de repérer ou de corréler les extrémités distale et proximale des capillaires. L'invention concerne de plus de procédés et un équipement servant à identifier des jeux ordonnés de microéchantillons défectueux auxquels il manque une ou plusieurs sondes de surface.

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