Microarray for the analysis of nucleotide sequences

Details Microarray for the analysis of nucleotide sequences Microarray for the analysis of nucleotide sequences

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2715538

A microarray for the analysis of single-stranded nucleotide sequences, in particular miRNAs, comprising a plurality of probe strands (5) bound to a substrate (2) and adapted to form respective probe hybrids (1) with a labelling segment (3) bound to a fluorophore moiety (4) and with a ligating segment. Each of the probe strands (5) consists of a complementary ligating sequence hybridised in use to the ligating segment, a complementary labelling sequence (8) hybridised in use to the labelling segment (3), and a probe sequence (7) positioned between the complementary ligating sequence and the complementary labelling sequence (8) and adapted to selectively ligate a target single-stranded nucleotide sequence.

L'invention porte sur un microréseau pour l'analyse de séquences nucléotidiques simple brin, en particulier de miARN comprenant une pluralité de brins sondes (5) fixés à un substrat (2) et aptes à former des hybrides de sonde respectifs (1) avec un segment de marquage (3) lié à une fraction fluorophore (4) et avec un segment de ligature. Chacun des brins sondes (5) est constitué d'une séquence de ligature complémentaire hybridée à l'utilisation au segment de ligature d'une séquence de marquage complémentaire (8) hybridée à l'utilisation au segment de marquage (3) et d'une séquence de sonde (7) placée entre la séquence de ligature complémentaire et la séquence de marquage complémentaire (8) et apte à ligaturer sélectivement une séquence nucléotidique simple brin cible.

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