C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2442820
A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-agressive CC-RCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor and normal tissue and methods of using them are disclosed.
L'invention concerne une sonde d'acide nucléique ou un nouvel ensemble de telles sondes dans un microréseau. La sonde ou l'ensemble de sondes est utile dans le pronostic de patients atteints d'un adénocarcinome à cellules claires (CC-RCC), des types de tumeurs agressives et non agressives CC-RCC étant caractérisés par des profils d'expression différentiels de gènes s'hybridant avec une ou plusieurs sondes. L'invention concerne également des microréseaux ou des kits permettant d'établir des profils de tumeur ou de tissus normaux, ainsi que des procédés d'utilisation de ceux-ci.
Haab Brian
Rhodes Daniel
Takashi Masayuki
Teh Bin Tean
Smart & Biggar
Van Andel Institute
Van Andel Research Institute
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