Microarray synthesis instrument and method

Details Microarray synthesis instrument and method Microarray synthesis instrument and method

B - Operations, Transporting

01

J

B01J 19/00 (2006.01) B01J 19/12 (2006.01) C12M 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2474638

During the light illumination period of a monomer addition cycle in synthesizing an DNA microarray, undesirable reflections of illumination light from various interfaces that the illumination light passes through near the synthesis surface of the substrate may reduce the light dark contrast, and negatively affect the precision and resolution of the microarray synthesis. The present invention provides an flow cell that reduces the undesired reflections by constructing certain flow cell structures with materials that have similar refractive indexes as that of the solution that is in the oligomer synthesis chamber during the illumination period and/or constructing certain flow cell structures or covering the structures with a layer of a material that has a high extinction coefficient.

Durant la période d'éclairage d'un cycle d'adjonction de monomères lors de la synthèse d'un microréseau d'ADN, des réflexions non souhaitables de lumière provenant de plusieurs interfaces à travers lesquelles la lumière circule à proximité de la surface de synthèse du substrat, peuvent réduire le contraste lumière/obscurité, et nuire à la précision et à la résolution de la synthèse du microréseau. La présente invention concerne également une cuve de circulation permettant de réduire les réflexions non souhaitables. Pour ce faire, il convient de fabriquer certaines structures de cuves de circulation au moyen de matériaux présentant des indices de réfraction similaires à ceux de la solution qui est contenue dans la chambre de synthèse des oligomères pendant la période d'éclairage, et/ou de fabriquer certaines structures de cuves de circulation, ou recouvrir ces structures, au moyen d'une couche d'un matériau présentant un fort coefficient d'extinction.

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