G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) C07H 21/00 (2006.01) G01N 33/545 (2006.01)
Patent
CA 2491618
Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library synthesis, distribution, and spotting of array elements onto solid planar substrates, labeling of complex protein mixtures, and the analysis of differential protein binding to the array. The invention also enables the enrichment or purification, and subsequent sequencing or structural analysis of proteins that are identified as differential by the array screen. Kits including proteomic microarrays in accordance with the present invention are also provided.
l'invention concerne des r~seaux de liaison ~ des prot~ines peptidomim~tiques, ainsi que leur fabrication, utilisation et application. Le r~seau de liaison ~ des prot~ines de l'invention comprend un segment peptidomim~tique reli~ ~ un support solide via un ancrage stable. L'invention concerne la synthse d'une librairie d'~l~ments de r~seaux peptidomim~tiques, la distribution et le rep~rage d'~l~ments de r~seaux sur des substrats solides plans, le marquage de m~langes prot~iques complexes et l'analyse de liaisons prot~iques diff~rentielles avec le r~seau. Cette invention permet ~galent de proc~der ~ un enrichissement ou ~ une purification ainsi qu'au s~quen×age ou ~ l'analyse structurelle ult~rieurs de prot~ines identifi~es comme diff~rentielles par le criblage du r~seau. Sont ~galement d~crites des trousses renfermant les micror~seaux prot~omiques selon la pr~sente invention.
Beausoleil Eric
Charych Deborah
Zuckermann Ronald N.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
LandOfFree
Microarrays on mirrored substrates for performing proteomic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microarrays on mirrored substrates for performing proteomic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microarrays on mirrored substrates for performing proteomic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1386227