C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/36 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2463482
Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods for immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.
L'invention concerne des compositions comprenant un microbe à mutation d'atténuation renfermant un terminateur de transcription recombinant inséré dans un gène chromosomique. Ces compositions peuvent être utilisées comme vaccins ou véhicules destinés à l'administration d'une protéine souhaitée à un individu. L'invention concerne en outre des méthodes d'immunisation d'un individu et des méthodes d'administration d'un produit génétique souhaité à un individu. Ces méthodes se basent sur l'administration de ces compositions.
Curtiss Roy III
Tinge Steven A.
Curtiss Roy III
Megan Health Inc.
Smart & Biggar
Tinge Steven A.
Washington University Of St. Louis
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