Microbial n- and o-demethylation of a thebaine derivative

Details Microbial n- and o-demethylation of a thebaine derivative Microbial n- and o-demethylation of a thebaine derivative

C - Chemistry, Metallurgy

07

D

C07D 489/12 (2006.01) C12P 17/04 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2484985

The invention provides a process for the N-demethylation or the N- and O- demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from the filamentous fungi from Cunninghamella dalmatica NRRL 1394, Cunninghamella echinulata NRRL 1387, Cunninghamella echinulata NRRL 1384, Cunninghamella echinulata ATCC 36190, Cunninghamella echinulata ATCC 11585a, Cunninghamella echinulata ATCC 9244, Cunninghamella polymorpha NRRL 1395, or Rhizopus nigricans Z5/1in a basal fermentation medium at a temperature of at least 25~C and not more than 34~C, for a period of time of at least 3 days.

L'invention concerne un procédé de N-déméthylation ou de N- et de O-déméthylation d'un dérivé de thébaïne, qui consiste à faire fermenter ce dérivé au moyen d'un biocatalyseur sélectionné dans le groupe de champignons filamenteux comprenant Cunninghamella dalmatica NRRL 1394, Cunninghamella echinulata NRRL 1387, Cunninghamella echinulata NRRL 1384, Cunninghamella echinulata ATCC 36190, Cunninghamella echinulata ATCC 11585a, Cunninghamella echinulata ATCC 9244, Cunninghamella polymorpha NRRL 1395, ou Rhizopus nigricans Z5/1 dans un milieu de fermentation de base à une température d'au moins 25 ·C et ne dépassant pas 34 ·C, pendant au moins 3 jours.

Affiliated with

Also associated with

Rating

Microbial n- and o-demethylation of a thebaine derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microbial n- and o-demethylation of a thebaine derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbial n- and o-demethylation of a thebaine derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1474787