Microbial preparation of 13.beta.-13-deoxy-22,23-dihydro...

Details Microbial preparation of 13.beta.-13-deoxy-22,23-dihydro... Microbial preparation of 13.beta.-13-deoxy-22,23-dihydro...

C - Chemistry, Metallurgy

12

N

C12N 1/14 (2006.01) C12P 17/18 (2006.01) C12P 19/02 (2006.01)

Patent

CA 2050826

18113 TITLE OF THE INVENTION MICROBIAL PREPARATION OF 13.beta.-13-DEOXY-22,23-DIHYDRO AVERMECTIN-Bla/Blb AGLYCONE ABSTRACT OF THE DISCLOSURE The known compound, 13.beta.-13-deoxy-22,23- dihydro-avermectin -Bla/81b Aglycone is prepared microbiologically from cultures of the novel microorganisms (MA-6762, ATCC 55069, MA-6763 ATCC 55070) or the known microorganism Streptomyces lavendulae MA-6555 (ATCC 14159). The compound is prepared by the biotransformation of 13-deoxy-22,23- dihydro avermectin Bla/Blb aglycone which oxidizes the 13-position and epimerizes the 13-position hydroxy group.

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