C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C12N 1/21 (2006.01) C12N 9/04 (2006.01) C12P 1/04 (2006.01) C12P 13/22 (2006.01)
Patent
CA 2328598
The invention relates to a process for microbially preparing substances from aromatic metabolism, in particular aromatic amino acids. In addition, the invention relates to gene structures and transformed cells. According to the invention, an increase in the production of substances, in particular aromatic amino acids, is observed by introducing or increasing the activity of a glucose dehydrogenase. Increasing the activity of a glucose-oxidizing enzyme leads to the intracellular formation of gluconolactone and gluconic acid from glucose-containing substrates. In a preferred embodiment, the glucose dehydrogenase is derived from Bacillus megaterium. The process according to the invention can be used to provide a wider spectrum of substances.
L'invention concerne un procédé de préparation microbienne de substances à partir d'un métabolisme aromatique, plus particulièrement d'acides aminés aromatiques. L'invention concerne, en outre, les structures géniques et les cellules transformées. Selon l'invention, on observe une augmentation de la production de substances, notamment d'acides aminés aromatiques, suite à l'introduction ou à l'augmentation de l'activité d'une glucose déhydrogénase. Cette augmentation de l'activité d'une enzyme catalysant l'oxydation du glucose entraîne la formation intracellulaire de gluconolactone et d'acide gluconique à partir de substrats renfermant du glucose. Selon un mode de réalisation préférentiel, la glucose déhydrogénase est dérivée du Bacillus megaterium. Le procédé peut être mis en oeuvre pour fournir une gamme plus variée de substances.
Karutz Martin
Kraemer Marco
Sahm Hermann
Sprenger Georg
Dsm Biotech Gmbh
Fetherstonhaugh & Co.
Forschungszentrum Julich Gmbh
Holland Sweetener Company V.o.f.
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