Microbial preparation of substances from aromatic metabolism/i

Details Microbial preparation of substances from aromatic metabolism/i Microbial preparation of substances from aromatic metabolism/i

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07H 11/04 (2006.01) C07K 14/195 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 15/31 (2006.01) C12P 1/00 (2006.01) C12P 13/22 (2006.01) C12P 19/02 (2006.01)

Patent

CA 2269800

The invention makes available, by means of an increased provision of intracellular metabolic intermediates, in particular of erythrose 4-phosphate, alternative processes for the microbial preparation of substances, in particular of aromatic amino acids such as L-phenylalanine, in which processes the activity of a transaldolase is increased in a microorganism producing these substances. In preferred embodiments of the invention, the activity of a transketolase or the activity of a transport protein for the PEP-independent uptake of a sugar and/or the activity of a kinase which phosporylates the relevant sugar are/is additionally increased. The invention also relates to gene structures, and to transformed cells carrying these gene structures, which make it possible to implement these processes in a particularly successful manner.

La présente invention se rapporte à de nouveaux procédés de préparation microbienne de substances, et notamment d'acides aminés aromatiques tels que la L-phénylalanine, lesdits procédés faisant un usage accru d'intermédiaires métaboliques intracellulaires, et notamment d'érythrose-4-phosphate, et lesdits procédés consistant à accroître l'activité d'une transaldolase dans un micro-organisme produisant de telles substances. Dans les réalisations préférées de l'invention, on accroît en outre l'activité d'une transcétolase ou l'activité d'une protéine de transport conçue pour assurer l'apport, indépendant du phosphoénolpyruvate (PEP), d'un sucre et/ou l'activité d'une kinase qui phosphoryle le sucre en question. L'invention se rapporte également à des structures géniques et à des cellules transformées portant ces structures géniques, qui permettent une mise en oeuvre particulièrement réussie de ces procédés.

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