C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) C07C 69/33 (2006.01) C12P 7/62 (2006.01)
Patent
CA 2361701
The present invention relates to a new microbial process for the preparation of compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6.beta.-hydroxylate a compound of Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6.beta.-hydroxylate a compound of general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.
L'invention concerne un nouveau procédé microbien pour la préparation du composé représenté par la formule (I), à partir d'un composé de formule générale (II). R est un métal alcalin ou un ion ammonium. Le procédé consiste à mettre en culture immergée une souche de moisissure capable d'engendrer la 6 beta -hydroxylation d'un composé de formule (II) en fermentation aérobie, et à séparer puis à purifier le produit de formule (I) issu de la bioconversion. On réalise la culture d'une souche de moisissure filamenteuse Mortierella maculata capable d'engendrer la 6 beta -hydroxylation d'un composé de formule (II), sur un support nutritif renfermant des sources de carbone et d'azote et des sels minéraux assimilables, et on sépare ensuite le produit issu du bouillon de fermentation avant d'isoler et de purifier le composé de formule (I). L'invention concerne en outre de nouvelles souches de Mortierella maculata.
Albrecht Karoly
Ambrus Gabor
Andor Attila
Barta Istvan
Bidlo Nee Igloy Margit
Institute For Drug Research Ltd.
Ridout & Maybee Llp
LandOfFree
Microbial process for preparing pravastatin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microbial process for preparing pravastatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbial process for preparing pravastatin will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1410453