Microbial process for preparing pravastatin

Details Microbial process for preparing pravastatin Microbial process for preparing pravastatin

C - Chemistry, Metallurgy

07

C

C07C 69/74 (2006.01) C07C 61/12 (2006.01) C07C 67/02 (2006.01) C12P 7/42 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2373544

The present invention relates to a new microbial process for the preparation of the compound of formula (I) from a compound of general formula (II) wherein R+ stands for an alkali metal or ammonium ion, by the submerged cultivation of the strain able to 6.beta.-hydroxylate a compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion, which comprises cultivating a strain of the genera Micromonospora able to 6.beta.-hydroxylate a compound of the general formula (II), wherein R+ is as defined above, on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts at 25-32 ~C, thereafter feeding the substrate to be transformed into the developed culture, then fermenting the substrate until the end of bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.

L'invention concerne un nouveau procédé microbien de préparation d'un composé de formule (I) à partir d'un composé de formule générale (II), dans laquelle R?+¿ représente un métal alcalin ou un ion ammonium, par culture submergée du brin capable d'6.beta.-hydroxylation d'un composé de formule (II) dans une fermentation aérobie et par séparation et purification du produit de formule (I) formé au cours de la bioconversion. Cette dernière consiste à cultiver un brin du genre Micromonospora capable d'6.beta.- hydroxylation d'un composé de formule générale (II), où R?+¿ est défini comme ci-dessus, sur un support de nutriment contenant des sources d'azote et de carbone assimilables et des sels minéraux à 25-32 ·C, puis à alimenter le substrat à transformer dans la culture développée, à fermenter le substrat jusqu'à la fin de la bioconversion, puis à séparer le composé de formule (I) du bouillon de culture, et si nécessaire à le purifier.

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