Microbial production of cephalosporin type antibiotic

Details Microbial production of cephalosporin type antibiotic Microbial production of cephalosporin type antibiotic

C - Chemistry, Metallurgy

12

P

195/97

C12P 19/00 (2006.01)

Patent

CA 1044627

Abstract of the Disclosure 7-[D-.alpha.-Amino-.alpha.-(p-hydroxyphenyl)acetamido]-3- (1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and its nontoxic, pharmaceutically acceptable salts exhibit highly desirable solubility in water, are efficiently absorbed on oral administration to provide relatively high and prolonged blood levels and are potent antibacterial agents useful in the treatment of infectious diseases in animals, including man, caused by many Gram-positive and Gram-negative bacteria. 7-[D-.alpha.-Amino-.alpha.-(p-hydroxyphenyl)acetamido]-3- (1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxlic acid is prepared, for example, by contacting methyl D-(-)-.alpha.-amino-.alpha.-(4-hydroxylphenyl)acetate or an acid addition salt thereof with 7-amino-3-(1,2,3-triazol- 5-ylthiomethyl)-3-cephem-4-carboxylic acid or a salt thereof in aqueous solution in the pressure of enzyme derived from a microorganism selected from the group consisting of Xanthomonas citri (IFO 3835), Acetobacter turbidans (ATCC 9325) and Pseudomonas melanogenum (IFO 12020).

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